Abstract
Multipotent progenitor cells have appealing characteristics such that they can self divide or develop into virtually any given cell type depending on environmental factors. Lineage-affiliated transcription factors govern the specification of a given cell lineage. A concern is how lineage -determining transcription factors lead to the stability of progenitor cells, committing to a specific cell line. Binary cell fate decisions can be governed mathematically by circuits that generate attractors corresponding to specified lineages. Bifurcations represent cell divisions and stage differentiation from lineage specific attractors. The findings of the constructed model represent that stages of stem cell differentiation through auto-regulation, inhibition and degradation factors can be analyzed mathematically by the stability of the stochastic and deterministic features within the system.
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