Abstract
The dynamic behavior of the tumor suppressor p53 as an important signal in response to various stresses can influence cellular fate decisions. Programmed cell death 5 (PDCD5) and wild type p53-induced phosphatase 1 (Wip1) regulate p53 dynamics as its activator and inhibitor, respectively. In the present study, we add Wip1 to p53-Mdm2 (Murine double minute 2) module with PDCD5 and focus on p53 dynamics depending on PDCD5 and ataxia telangiectasia mutated (ATM) degradation rate regulated by Wip1. The bifurcation results reveal that p53 dynamics varies with these two parameters. p53 exhibits monostability and bistabiltiy for smaller and larger PDCD5 level while p53 shows oscillation or coexistence of oscillation and steady states in a narrow parameter range. These dynamics are further explored by time series and potential landscapes. Our results may be useful for regulating cell fate upon DNA damage.
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