Abstract
Research disclosed since the demonstration of the first examples of primary amine-thiourea organocatalysis in 2006 has shown that primary amine-based thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds. Recent remarkable progress with these chiral catalysts is summarized in this review.
Highlights
View Article OnlineResearch disclosed since the demonstration of the first examples of primary amine-thiourea organocatalysis in 2006 has shown that primary amine-based thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds
Asymmetric organocatalysis has emerged as a powerful and environmentally friendly and mild methodology for the catalytic production of enantiomerically pure natural products, chiral drugs, building-blocks, and important molecules for materials chemistry.[1,2] In many cases, the effectiveness of organocatalysts relies on the hydrogen bonding interactions: e.g. non-covalent catalysis with thioureas and ureas, diols and amidinium cations.[3,4] thiourea derivatives have become a subject of considerable interest for catalyst design in recent years.[4]
Research disclosed since the demonstration of the first examples of primary amine-thiourea organocatalysis in 2006 has shown that primary amine-based thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds
Summary
Research disclosed since the demonstration of the first examples of primary amine-thiourea organocatalysis in 2006 has shown that primary amine-based thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds. Recent remarkable progress with these chiral catalysts is summarized in this review.
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