Abstract
There is a huge demand for materials capable of simple detection or separation after conjugation with specific biologic substances when applied as a diagnostic tools. Taking into account the photoluminescence properties of C-dots and the highly magnetic properties of Fe(0), a new hybrid composite of these components was synthesized via ultrasound irradiation. The material was fully characterized by various physicochemical techniques. The main goal of the current study was to obtain a highly magnetic and intense fluorescent hybrid material. The goal was achieved. In addition, magnetic particles tended to agglomerate. The new hybrid can be suspended in ethanol, which is an additional feature of the current research. The dispersion of the hybrid nanoparticles in ethanol was achieved by utilizing the interaction of iron particles with C-dots which were decorated with functional groups on their surface. The newly formed hybrid material has potential applications in diagnostic by conjugating with specific antibodies or with any other biologic compounds. Such application may be useful in detection of various diseases such as: cancer, tuberculosis, etc.
Highlights
The ability of magnetic nanoparticles to be directed to a specific organ in the human body by an external field makes these particles very viable for biomedical applications [1,2,3]
The combination of magnetite Fe3O4 nanocrystals and fluorescent carbon dots (C-dots) in porous carbon was synthesized by the solvothermal method [11]
The carbon/Fe3O4 hybrid C-dots with oligomers of ethylene glycol or polyethyleneimine for surface functionalization and passivation have been prepared in a thermal carbonization synthesis using microwave energy, coupled with magnetic separation [12]
Summary
The ability of magnetic nanoparticles to be directed to a specific organ in the human body by an external field makes these particles very viable for biomedical applications [1,2,3]. The stability and biocompatibility of magnetic nanoparticles (NPs) may be significantly improved by coating with either inorganic (silica, hydroxyapatite) or organic (chitosan, collagen, polyethylene glycol) materials to modify their surface [5,6,7]. Several studies have been report combining C-dots with magnetic nanomaterials and developing multifunctional systems for biomedical application. The combination of magnetite Fe3O4 nanocrystals and fluorescent C-dots in porous carbon was synthesized by the solvothermal method [11]. The carbon/Fe3O4 hybrid C-dots with oligomers of ethylene glycol or polyethyleneimine for surface functionalization and passivation have been prepared in a thermal carbonization synthesis using microwave energy, coupled with magnetic separation [12]. The low emission intensity was a result of a possible quenching effect due to the presence of magnetite in the dot structure [13]
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