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Abstract
Juvenile papillomatosis (JP), also termed Swiss cheese disease, is a rare and benign type of proliferative breast tumor that is specifically observed in children and adolescents. The majority of JP patients are Caucasian and exhibit a single breast mass. The current report presents an unusual case of bifocal JP in an 11-year-old Chinese female. The patient presented with a slow-growing palpable mass in the upper outer quadrant of the left breast. Ultrasonography identified a further impalpable lesion in the lower outer quadrant of the ipsilateral breast. The preoperative clinical diagnosis of the two masses was fibroadenoma, however, following complete excision of the two tumors, histopathology revealed JP. Furthermore, the patient had a family history of breast cancer. The current report describes a review of the literature regarding the presentation, pathology, diagnosis, and treatment of JP and its association with breast carcinoma. In the current case, JP was associated with an increased risk of breast cancer in the patient, as well as the patient’s elder female relatives; therefore, a more thorough medical follow-up may prove prudent for those individuals with a high risk of developing breast cancer.
Highlights
Juvenile papillomatosis (JP), termed Swiss cheese disease, of the breast is a rare and benign disease, whichKey words: juvenile papillomatosis, diagnosis and treatment, breast cancer risk predominantly occurs in females aged
Since JP was first presented by Rosen et al [1] in 1980, ~400 cases have been reported, with the majority observed in Caucasian patients and rare cases occurring in patients of Asian origin [4]
A long‐term follow‐up study demonstrated that certain patients developed breast cancer eight‐nine years subsequent to the diagnosis of JP [8]; JP patients appear to have an increased risk of developing breast cancer
Summary
Juvenile papillomatosis (JP), termed Swiss cheese disease, of the breast is a rare and benign disease, which. A firm, mobile, poorly‐circumscribed, tender mass was identified in the upper outer quadrant of the left breast, 1 cm from the areola (size, 3x3x2 cm). The first lesion was located in the lower outer quadrant of the left breast (size, 0.9x0.5x1.0 cm) and did not exhibit subcutaneous association with the primary lesion. The second lesion was identified in the upper outer quadrant of the right breast (size, 0.6x0.4x0.4 cm). The patient and the patient's parents selected medical follow‐up examinations for the mass in the right breast, rather than surgery or a core needle biopsy; the two lesions in the left breast were completely excised. Regular patient follow‐up, by physical examination and ultrasonography of the breasts, is ongoing, and to date has been conducted for 48 months. Further follow‐up did not indicate the development of new breast disorders among the patient's relatives
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