Bifidobacterium longum subsp. longum KACC 91563 from Korean neonates alleviate the food allergy by decrease of mast cells in the gut. (P3172)

Abstract

Abstract Gut microbiota which establish the habitat in our gut, have formidable effects on human body via complex mechanisms, including metabolism, development, behavior, immune defense and diseases. Probioitcs are live microorganism that confers a benefit on the host when administrated adequate amount. Food allergy is a potentially serious disease caused by abnormal immune response to food or food additives and hospital visits for food allergy have been dramatically increased in the last several decades. Here we investigated the effects of new probiotics that isolated from the feces of healthy Korean infants on food allergy. Among them, we found that new subspecies of Bifidobacterium Longum suppress the diarrhea in allergen-induced food allergy mouse model. When we administrated B. longum subsp. longum KACC 91563, the accumulation of mast cells was significantly decreased in small intestinal lamina propria and mast cell proteases were down regulated in serum. However Th1, Th2, Th17 and regulatory T cells were not involved in the alleviation of allergen-induced food allergy in small intestinal lamina propria. These findings suggest that oral administration of newly isolated B. longum, ameliorates the severity of allergen-induced food allergy by decrease of mast cells.