Abstract
Repeated spaced injections into the amygdala (AM) of rats of a subconvulsive dose of either l-glutamate (GLU) or l-aspartate (ASP) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled seizure. Both GLU- and ASP-kindled AM sites responded to electrical stimulation with very rapid development of kindled seizure. When electrically kindled AM sites received identical injections of GLU or ASP, a similar positive transfer effect was obtained. These results suggest that (1) either GLU or ASP alone can kindle the AM and (2) GLU, ASP or GLU/ASP kindling share common neurobiological mechanisms with electrical kindling.
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