Abstract
Bidirectional talk between AhR and Oct4.
Highlights
The aryl hydrocarbon receptor (AhR) is a member of the family of basic helix-loop-helix transcription factors that is widely expressed in most differentiated mammalian cells and implicated in a variety of cellular processes, such as cell cycle progression, cell migration, carcinogenesis and immune functions
By RNA sequencing-based analysis, it was implicated that the overall effect of TCDD-driven AhR activation was to maintain the pro-proliferative state of mouse embryonic stem cells (ESCs) and inhibit their differentiation into cardiomyocytes
The results from a subsequent study showed that AhR expression was maintained in a repressed but poised state in mouse ESCs which allowed for its quick activation during differentiation
Summary
The aryl hydrocarbon receptor (AhR) is a member of the family of basic helix-loop-helix transcription factors that is widely expressed in most differentiated mammalian cells and implicated in a variety of cellular processes, such as cell cycle progression, cell migration, carcinogenesis and immune functions. By RNA sequencing-based analysis, it was implicated that the overall effect of TCDD-driven AhR activation was to maintain the pro-proliferative state of mouse embryonic stem cells (ESCs) and inhibit their differentiation into cardiomyocytes. In TCDD-treated AhRpositive differentiating ESCs, key pluripotency-associated transcription factors such as Oct4, Sox2, Nanog, Klf4 were all predicted to be activated at the transcriptional level [2], indicating a potential connection between AhR signaling and the core pluripotency factors.
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