Abstract
Abstract The addition of 1.5 × 107 F1 spleen cells to inocula of parental thymocytes in sublethally irradiated F1 hosts influenced the resultant splenomegaly. The influence of the F1 cells was bidirectional; under certain conditions they increased the splenomegaly while under others they decreased it. Analysis of these conditions revealed that the effect the F1 cells had depended on the activity of the parental thymocytes. Active thymocytes produced small spleens when inoculated alone; the smaller the spleen the greater the synergy with F1 cells. On the other hand less active thymocytes occasionally produced some splenomegaly on their own. When they did, added F1 cells reduced the spleen size (acted “antergistically”). The mechanism(s) by which these bidirectional effects of F1 cells may be expressed are discussed.
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