Abstract
BackgroundDisturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic-like pain symptoms.MethodsA total of 423 individuals who had undergone total joint replacement (TJR) for osteoarthritis were assessed at the mean time of 3.6 years post-surgery and again at 5.9 years post-TJR, using the Medical Outcomes Survey sleep subscale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and painDETECT questionnaire instruments. Cox hazard ratios (HRs) and 95% confidence intervals (CIs) were computed adjusting for age, body mass index, sex, and use of hypnotic and analgesic medication.ResultsThe presence of neuropathic pain symptoms predicted incidence of disturbed sleep after adjustment for covariates and pain severity (adjusted HR [aHR] 2.01, 95% CI: 1.00–4.10; p<0.05). There was no association between joint pain and incidence of disturbed sleep when individuals with neuropathic pain symptoms at the baseline visit were excluded (aHR 1.11, 95% CI: 0.47–2.67). Disturbed sleep at baseline predicted incident neuropathic joint pain symptoms (aHR 2.75, 95% CI: 1.21–6.26; p<0.016) but had no effect on incidence of joint pain when all types of pain were considered together (aHR 0.63, 95% CI: 0.30–1.39).ConclusionThese data suggest a causal bidirectional link between sleep disturbance and joint pain with neuropathic features but not with other types of joint pain.
Highlights
Disturbed sleep is a frequent complaint of people experiencing chronic pain such as those with knee osteoarthritis (OA).[1]
Given the links between descending pain inhibition and sleep, we focused in particular on the links between disturbed sleep and neuropathic pain seeking to answer two study questions: 1) is the link between chronic joint pain and sleep mediated by the presence of neuropathic pain symptoms? and 2) does sleep disturbance predict the development of neuropathic pain symptoms over a 2-year period?
27% of individuals had severe joint pain, 24% of them had neuropathic pain symptoms and one-third of them fell within the disturbed sleep category
Summary
Disturbed sleep is a frequent complaint of people experiencing chronic pain such as those with knee osteoarthritis (OA).[1]. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic-like pain symptoms. Results: The presence of neuropathic pain symptoms predicted incidence of disturbed sleep after adjustment for covariates and pain severity (adjusted HR [aHR] 2.01, 95% CI: 1.00–4.10; p
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
