Bidens pilosa L. (Asteraceae) cultivated in Brazil on acute liver disease in dogs

A.V.C Amaral,J.R Paula,M.C.S Fioravanti,A.P.A Costa,L.C Cunha,L.S Oliveira,L.M.L Parente,E.C Conceição,L.A.T Benatti

doi:10.1590/1678-4162-11168

Abstract

ABSTRACT Bidens pilosa L. is a medicinal plant popularly used for treatment of liver diseases. In this study, the dry extract of aerial parts of Bidens pilosa and Silymarin, a phytocomplex obtained from the Silybum marianum fruits and marketed as hepatoprotective, were tested in dogs experimentally acutely intoxicated with carbon tetrachloride. The liver activity was evaluated by hematological and biochemical profiles, and histological and ultrasound analyzes. It was observed that the lowest serum activities of ALT and serum concentrations of total bilirubin occurred in the groups treated with the dry extract of Bidens pilosa, while only decreased serum concentrations of total bilirubin occurred in the group treated with Silymarin. Best liver recovery was also observed for the dry extract of B. pilosa at a 400mg/Kg dose by ultrasonography. This study showed that the dry extract of Bidens pilosa acted more efficiently in the treatment of acute toxic hepatitis induced in dogs than Silymarin.

Highlights

Bidens pilosa L. belongs to the Asteraceae family originated from South America, is popularly known in Brazil as picão, picão preto, marcelado-campo and carrapicho de agulha and in the USA as black-jack, beggar-ticks, cobbler's pegs and Spanish needle, and grows spontaneously in agricultural crops in all regions of Brazil
In the 100mg and 400mg ethanolic extract of Bidens pilosa (EEB) groups, vomiting ceased in the 3rd and 4th days after intoxication, respectively, while in the Silymarin and control groups vomiting remained until the 8th day
Diarrhea episodes ceased in the 100mg and 400mg EEB groups on the 5th day after intoxication and in the Silymarin and control groups it remained until the 18th day

Summary

Introduction

Bidens pilosa L. belongs to the Asteraceae family originated from South America, is popularly known in Brazil as picão, picão preto, marcelado-campo and carrapicho de agulha and in the USA as black-jack, beggar-ticks, cobbler's pegs and Spanish needle, and grows spontaneously in agricultural crops in all regions of Brazil. There is even a specific monograph on Bidens pilosa prepared by the Ministry of Health (Brasil, 2015)

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