Abstract
BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouseBidand humanBIDgenomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localizeBidto the distal region of mouse chromosome 6 near theAtp6elocus. Fluorescencein situhybridization analysis localized humanBIDto a syntenic human region, chromosome 22q11, close to theBCR-1gene.
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