Abstract

Indolizidine is a ring system present in many families of natural alkaloids that have been discovered and synthesized in recent years for their important biological activity. These belong principally to the classes of amphibian alkaloids and imino sugars. This review focuses on the development of modern synthetic methods aimed at the synthesis of the indolizidine ring system, in particular those employing cycloadditions and multicomponent reactions, domino and radical reactions, and metal-catalyzed reactions, particularly ring opening, ring closing, and cross-metatheses. Several examples of synthesis of natural alkaloids and important bioactive compounds containing the indolizidine nucleus using these methodologies are reported and systematically compared.

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