Abstract
Abstract Introduction We use 4D Flow MRI to (1) investigate the effects of bicuspid aortic valve (BAV) disease on downstream pressure drop (PD), wall shear stress (WSS), and viscous energy loss (EL) in the ascending aorta (AAo) and (2) explore the associations between AAo diameter and PD, WSS, and EL. Hypothesis BAV patients show increased PD, WSS, and EL in the AAo compared to age-matched controls Methods 32 healthy controls (41±15 y, 10 female) and 53 BAV patients (44±16 y, 19 female) underwent cardiac MRI at 3T, inclusive of cine imaging and 4D flow. Cross sections were placed along segmented aortas at the: left ventricular outflow tract (LVOT), sinuses of Valsalva (SOV), mid-ascending aorta (MAA), and proximal to first aortic branch (AA1). Locations were analyzed for (i) net flow, (ii) aortic diameter (normalized to BSA), (iii) systolic PD (referenced to LVOT), (iv) systolic EL (measured within LVOT-AA1 volume and normalized by LVOT net flow; mW/mL), and (v) systolic WSS. Sub-vectors of WSS, axial (WSSax) and circumferential (WSScirc), were also analyzed. Results In comparison to controls, BAV patients showed greater PD (e.g. MAA: 9.5±8.0 vs. 2.8±2.4mmHg; p<0.01), EL (0.09±0.05 vs. 0.04±0.01 mW/mL; p≤0.01), and WSScirc (e.g. MAA: 0.3±0.1 vs. 0.2±0.06 Pa; p≤0.01) throughout the AAo (Table 1 and Fig. 1). BAV patients exhibited significantly lower WSS and WSSax only at the SOV. In univariate analyses, AAo diameter was inversely correlated with WSS (R=−0.32, p<0.01) and WSSax (R=−0.51, p≤0.01). In multivariate analyses, AAo diameter was associated with WSS (β=−0.36, p<0.01) and WSSax (β=−0.26, p<0.01). Conclusions BAV patients demonstrate significantly increased PD, EL, and WSScirc in the AAo, and an inverse association between AAo diameter and WSS measures. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Alberta Health Services
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