Bibliometric analysis of single cell sequencing in Parkinson’s disease

Abstract

Objective To provide a comprehensive understanding of the current research on Parkinson’s disease (PD) with the application of single cell sequencing (SCS) through bibliometric analysis. Methods With the keywords of “Parkinson’s disease” and “single cell sequencing”, all relevant literature were screened from the Web of Science. Research trends in related field were analyzed by using VOSviewer, Pajek, and PS software, to explore research hotspots, development trends, and future directions for PD based on SCS. Results The annual publication of SCS and PD increased. The United States had the most contribution to this field, followed by China. Among the top 10 institutions with the largest number of publications, Karolinska Institute, Institutions Lund University and University of Luxembourg have the strongest presence. In terms of influential authors, Parmar Malin stood out as the most prolific author while Marsden, Cd and Obeso Ja are the most influential investigators. During this period, the majority of publications and citations were found in Journal of Frontiers in Immunology and Scientific Reports. Keyword clustering analysis highlighted the increasing focus on the such pivotal pathological factor as alpah-synuclein. Conclusion Over the past 30 years, the growing number of high-quality publications has significantly contributed to the advancement of PD based on SCS, indicating a promising prospect for investigations on PD with the usage of SCS.