Abstract

Background: In recent years, research on the association between magnesium and bone has gained widespread attention. Magnesium plays an important role in bone health, and magnesium alloys and magnesium nanoparticles have potential applications as biomaterials in the field of orthopedics. Methods: This study employed a comprehensive literature review and analysis to summarize the interactions and application areas of magnesium and bone. Through bibliometric analysis, the research trends and international landscape of zinc and bone studies were evaluated. Results: The results indicate a continuous growth in research related to zinc and bone, with China playing a key role in this field. The Chinese Academy of Sciences was identified as the core institution for zinc and bone research, and Qin Ling emerged as a central author in this domain. The study also found that magnesium alloys hold potential for applications in orthopedic implant materials, while magnesium nanoparticles can promote bone formation and exhibit anti-inflammatory and antibacterial activities. Conclusions: This study emphasizes the importance of international collaboration and interdisciplinary research in advancing global research on zinc and bone. However, bibliometric analysis has certain limitations and should be complemented with qualitative methods and expert knowledge for comprehensive evaluation. Future research directions include optimizing the degradation performance of magnesium alloys, gaining a deeper understanding of the mechanisms underlying magnesium’s role in bone formation, and exploring innovative approaches such as functional coatings and material surface modification techniques. These findings provide valuable guidance and prospects for further exploration of the relationship between magnesium and bone and the development of innovative solutions for bone health.

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