Abstract

BackgroundThe status of research and scientific outputs with regards to bacterial central nervous system (CNS) infection in southeast Asia (SEA) is unknown. This study aimed to analyze and compare bacterial CNS infection research output of SEA countries in terms of bibliometric indices.MethodsThe major electronic databases (MEDLINE, Scopus, Embase, CENTRAL, Clinicaltrials.gov and WPRIM) were searched for studies on bacterial CNS infection in SEA until August 31, 2020. Frequencies, percentages and Spearman’s rho correlations were used.ResultsThere was a total of 648 unique studies on bacterial CNS infection in SEA and it was 657 when double-counted (collaborative studies between SEA countries). Thailand (n=148, 22.5%) and Vietnam (n=142, 21.6%) had the highest number of publications. The most common type of research publication was the case report / case series (n=160, 24.7%). Tuberculous meningitis/tuberculoma (n=176, 26.7%) was the most common topic. This study showed that the %GDP for research and development (R&D) was associated with a higher number of research output. However, the GDP per capita was not associated with any of the bibliometric indices. The total number of neurologists was associated with all of the bibliometric analysis.ConclusionBacterial CNS infection research output in SEA countries was low in terms of quantity. The %GDP for R&D was associated with the number of research publications. The total number of neurologists was associated with all of the bibliometric indices.

Highlights

  • Infection of the central nervous system (CNS) is one of the common neurologic conditions worldwide

  • Bacterial CNS infection research output in southeast Asia (SEA) countries was low in terms of quantity

  • The %Gross domestic product (GDP) for research and development (R&D) was associated with the number of research publications

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Summary

Introduction

Infection of the central nervous system (CNS) is one of the common neurologic conditions worldwide. CNS infections affected 10,425,058 people per year in the Southeast Asia (SEA). This remains high compared to other regions of the world [1]. The clinical presentations of bacterial CNS infection ranges from meningitis, encephalitis, or meningoencephalitis to focal CNS syndromes such as abscess [2]. Meningitis is the most common clinical presentation. The status of research and scientific outputs with regards to bacterial central nervous system (CNS) infection in southeast Asia (SEA) is unknown. This study aimed to analyze and compare bacterial CNS infection research output of SEA countries in terms of bibliometric indices

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