Abstract

Metabolic control in cells is mediated by the dynamic assemblies and function of multiple redox protein partner. A key element in these assemblies, the P450 oxidoreductase (POR), transfers electrons and selectively activates numerous cytochromes P450 (CYPs) (>50 in humans and >300 in plants). In doing so we showed that POR controls metabolism of drugs, steroids and xenobiotics in humans and natural product biosynthesis in plants12. The molecular mechanism governing POR-mediated CYP metabolism remain poorly understood and to date no ligand binding has been described to regulate the specificity of POR.

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