Abstract
The analysis on structural characteristic of proteins is helpful to understand molecular mechanisms of disordered structure formation and principles of protein folding, and can provide a foundation for predicting model of intrinsically disordered proteins. In this thesis, the significance test of structural bias of amino acid monomer, dimer and trimer between disordered and ordered regions is carried out by using Fisher Exact Test. The purpose is to probe the difference of amino acid compositions between disordered and ordered regions and analyze the effect of interaction between amino acids on structural formation. The results show that there are significant different amino acid compositions between disordered and ordered regions and between different length disordered regions. It is also found that the effect of every kind of amino acid on structural formation is different by the analysis of amino acid dimer and trimer. Therefore, it is a good way to achieve the folding principles of proteins by analyzing amino acids coding.
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