Bia-amperometric quantification of salbutamol in pharmaceutical products

Abstract

This paper presents a simple, rapid and reproducible method of analysis of salbutamol in pharmaceutical products, utilizing batch injection analysis (BIA) associated with amperometric detection. A study of salbutamol oxidation demonstrated a strong dependence between electrode fouling and pH. All determinations were done utilizing a glassy carbon electrode in presence of 3.0 mol l −1 NaOH. A large linear dynamic range from 8×10 −7 to 2×10 −4 mol l −1 was obtained by using an injected volume of 100 μl with a detection limit of 2.5×10 −7 mol l −1. R.S.D. of 0.92% for 50 successive injections of 4×10 −6 mol l −1 of salbutamol and a sample throughput of 60 samples per hour were achieved. The method was applied for salbutamol quantification in syrups.