Abstract
In the study reported, indomethacin tablets were prepared by direct compression. Microcrystalline cellulose and polysorbate 80 were used as excipients. Drug release was studied using a beaker method. The results revealed that no commonly used kinetic model could explain the pattern of release. A bi-exponential, first-order kinetic model was therefore offered. On the basis of this model, there was good correspondance between calculated and observed values. As a rule, polysorbate 80 enhanced both the faster and the slower rate constants of the bi-exponential model. In addition, the percentage of indomethacin dissolved according to the faster process was increased.
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