Abstract
Background: Pyrrolidine-based ring systems are ubiquitous in nature. (R)-Bgugaine is a 2-alkylated pyrrolidine alkaloid which has been isolated from the tubers of Arisarum vulgare, a toxic Araceae found along the Mediterranean coast. The construction of this heterocyclic ring system in an enantio-riched fashion has been the subject of attention in the recent years. This article covers the reports till 2016 on the isolation, biological activity studies and synthetic endeavours of bgugaine alkaloid. Keywords: Alkaloids, bgugaine, bioactivity, natural products, synthesis.
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