Abstract

Automatic and accurate segmentation of breast lesion regions from ultrasonography is an essential step for ultrasound-guided diagnosis and treatment. However, developing a desirable segmentation method is very difficult due to strong imaging artifacts e.g., speckle noise, low contrast and intensity inhomogeneity, in breast ultrasound images. To solve this problem, this paper proposes a novel boundary-guided multiscale network (BGM-Net) to boost the performance of breast lesion segmentation from ultrasound images based on the feature pyramid network (FPN). First, we develop a boundary-guided feature enhancement (BGFE) module to enhance the feature map for each FPN layer by learning a boundary map of breast lesion regions. The BGFE module improves the boundary detection capability of the FPN framework so that weak boundaries in ambiguous regions can be correctly identified. Second, we design a multiscale scheme to leverage the information from different image scales in order to tackle ultrasound artifacts. Specifically, we downsample each testing image into a coarse counterpart, and both the testing image and its coarse counterpart are input into BGM-Net to predict a fine and a coarse segmentation maps, respectively. The segmentation result is then produced by fusing the fine and the coarse segmentation maps so that breast lesion regions are accurately segmented from ultrasound images and false detections are effectively removed attributing to boundary feature enhancement and multiscale image information. We validate the performance of the proposed approach on two challenging breast ultrasound datasets, and experimental results demonstrate that our approach outperforms state-of-the-art methods.

Highlights

  • Breast cancer is the most commonly occurring cancer in women and is the second leading cause of cancer death Siegel et al (2017)

  • We propose a boundary-guided multiscale network (BGM-Net) to boost the performance of breast lesion segmentation from ultrasound images based on the feature pyramid network (FPN) Lin et al (2017)

  • We develop a boundary-guided feature enhancement module to improve the boundary detection capability of the feature map for each FPN layer by learning a boundary map of breast lesion regions

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Summary

Introduction

Breast cancer is the most commonly occurring cancer in women and is the second leading cause of cancer death Siegel et al (2017). Ultrasonography has been an attractive imaging modality for the detection and analysis of breast lesions because of its various advantages, e.g., safety, flexibility and versatility Stavros et al (1995). Clinical diagnosis of breast lesions based on ultrasound imaging generally requires well-trained and experienced radiologists as ultrasound images are hard to interpret and quantitative measurements of breast lesion regions are tedious and difficult tasks. Automatic localization of breast lesion regions will facilitate the process of clinical detection and analysis, making the diagnosis more efficient, as well as achieving higher sensitivity and specificity Yap et al (2018). Accurate breast lesion segmentation from ultrasound images is very challenging due to strong imaging artifacts, e.g., speckle noise, low contrast and intensity inhomogeneity.

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