Abstract
This article describes an open-access gene expression database analyzed for more than 2,000 genes on mouse nervous system tissue in the coronal, sagittal, and transverse orientation representing multiple developmental ages.
Highlights
The challenge of the postgenomic era is to assign functions to individual genes, and to determine how sets of genes act in concert to control biological processes
The Brain Gene Expression Map (BGEM) database contains a survey of gene expression patterns at four critical stages of mouse nervous system development: embryonic day 11.5 (E11.5), E15.5, postnatal day 7 (P7), and adult (P42)
We have identified gene expression patterns within the nervous system for many genes, including heat-shock 70kDa protein 12A (Hspa12a), keratocan (Kera), and dermatan sulfate proteoglycan 3 (Dspg3), that had previously been reported in only non-neuronal tissues (Figures S1I, S2C, and S2F)
Summary
The challenge of the postgenomic era is to assign functions to individual genes, and to determine how sets of genes act in concert to control biological processes This formidable task is even more daunting when one attempts to understand the complex genetic programs underlying nervous system development. Identifying the temporal and spatial expression patterns of these genes throughout development is a critical initial step that lays the groundwork for additional functional analyses. Toward this goal, we have developed a publicly available database of gene expression patterns, the St. Jude Brain Gene Expression Map (BGEM). GENSAT is supported by the National Institutes of Neurological Disorders and Stroke and by the National Institutes of Health Neurosciences Blueprint (http:⁄⁄neuroscienceblu eprint.nih.gov), a partnership of 14 NIH institutes and centers committed to accelerating understanding of the nervous system
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
