Abstract
Objective: Examine the role of basic fibroblast growth factor (bFGF) in the generation of reactive oxygen species (ROS) in FaDu pharyngeal carcinoma cell lines. Evaluate the consequences of disrupting bFGF mediated signaling in tumor cells. Method: Basic science study of hypopharyngeal carcinoma from 2010 to 2012. The study subjects were FaDu cell lines. Setting: In vitro. Interventions: Disrupting bFGF signaling. Outcomes Measured: ROS generation, apoptosis. Results: bFGF and fibroblast growth factor receptor are co-expressed in FaDu squamous cell carcinoma cells. ROS generation in FaDu cells takes place in response to bFGF stimulation, and is inhibited with a FGF receptor inhibitor, in a NADPH-oxidase dependent and cyclooxygenase-independent manner. Disrupting bFGF-FGFR signaling results in an early strong apoptotic stimulus involving caspase-3, -9, and poly ADP ribose polymerase. Conclusion: bFGF-mediated signaling in hypopharyngeal cancer has an important role in cell survival and proliferation.
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