Abstract
Beyond the Immune System: The Role of Resident Cells in Asthma and COPD
Highlights
Gosens focus on the role of acetylcholine in smooth muscle cell function and review data to show that the activation of acetylcholine receptors in these cells can lead to proliferation, production of growth factors, inflammatory mediators, and deposition of extra-cellular matrix proteins
Miglino et al present data on another novel target to reduce bronchial smooth muscle remodeling in their original research article. They show that calreticulin, which has been described as a negative regulator of C/EBPα [1], is able to reduce airway smooth muscle (ASM) cell proliferation and may provide beneficial effects on airway remodeling
Burgess review the history of expression microarray technologies, that is, genomewide association studies (GWASs)/locus fine mapping, gene candidate approaches, and gene expression studies, and their contribution to increase our understanding of asthma pathology
Summary
Gosens describe a novel role of the parasympathetic neurotransmitter acetylcholine in the regulation of airway remodeling and inflammation in respiratory disease. Recent data have indicateed that nonneuronal cells, including smooth muscle cells, secrete acetylcholine and express receptors for acetylcholine. Gosens focus on the role of acetylcholine in smooth muscle cell function and review data to show that the activation of acetylcholine receptors in these cells can lead to proliferation, production of growth factors, inflammatory mediators, and deposition of extra-cellular matrix proteins.
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