Abstract
The degree of polymorphism characteristic for hypervariable segments of mitochondrial DNA (mtDNA) is sometimes too low to enable differentiation between individuals revealing most frequent HV1 and HV2 haplotypes. An acceptable solution in such a situation seems to be analysis of additional variation present outside the control region. For practical and ethical reasons, analysis of variation present in the coding part of mitochondrial DNA should be limited to selected single nucleotide polymorphisms. Before selective SNP analysis is possible, those particular valuable mutations, which occur appropriately frequently in a population and are free of medical information, must be determined.
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