Abstract
The effects of exposure to chronic noise and vibration, produced by construction work, on the release and uptake of [ 3H]5-hydroxytryptamine ([ 3H]5-HT) and [ 14C]γ-aminobutyric acid ([ 14C]GABA) from rat amygdaloid and hippocampal slices were investigated. Noise-exposure resulted in increased release, with no significant change in uptake, of [ 14C]GABA from amygdaloid slices. In hippocampal slices, [ 14C]GABA release was also increased, but the changes in release were dependent upon the marked decrease in uptake of [ 14C]GABA into these slices. There was an increase in peak K +-evoked release of [ 3H]5-HT from hippocampal slices, but no other changes in [ 3H]5-HT release or uptake in either region were observed following noise-exposure. These findings may have important practical implications for the research carried out in laboratories exposed to construction noise and vibrations.
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