Abstract
Everybody, regardless of their role, is aware that biomedical research is rapidly evolving, and the demand for reproducibility is increasing together with the amount of novel information. “Before reproducibility must come pre-producibility” “Checklists work to improve science”, just to quote some of the articles querying how to find a new bridge between ethics in science and the urgency for publishing. Looking for papers on anti-inflammatory compounds in periodontics, we came across a significant number of articles that could be considered a prototype of a consistent study format. The literature on the testing of active compounds on lipopolysaccharides- (LPS)-induced inflammation in gingival fibroblasts was searched to identify studies that followed a consistent format, to better understand their similarities and assess the appropriateness of their methods. Several studies were identified with a degree of similarity in their methods and formatting that was so high that it was possible to rule out that it was due to chance, and a format template common to these studies was outlined. Although this was most likely beyond the intentions of their authors, these studies may pose the basis for an in-vitro testing standard for anti-inflammatory compounds; however, the dangers of acritical uniformity are also apparent.
Highlights
Testing the effectiveness of a chemical compound in a biological model means to challenge that model with an experimental stimulus and assess its responses using established, accepted and, possibly, standard measures
LPS is a critical component of Gram-negative bacteria, such as Porphyromonas Gingivalis, which is able to trigger the activation of Toll-Like Receptors, and inflammation [5]
While browsing the current literature on the effectiveness of chemical compounds in hampering the inflammatory response of human gingival fibroblasts, it became apparent that a growing number of publications are becoming aligned in terms of the reporting format
Summary
Testing the effectiveness of a chemical compound in a biological model means to challenge that model with an experimental stimulus and assess its responses using established, accepted and, possibly, standard measures. It is not surprising that the scientific community has long striven to achieve standard protocols in pre-clinical and clinical testing that could facilitate the interpretation of results and possibly streamline the development of new therapies and medications. Publications 2019, 7, 67 inflammation and to modulate tissue responses, blunting their antimicrobial effectiveness [6]. While browsing the current literature on the effectiveness of chemical compounds in hampering the inflammatory response of human gingival fibroblasts, it became apparent that a growing number of publications are becoming aligned in terms of the reporting format. A better understanding of this format may prove important to better tailor future publications to the real clinical needs of the field
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