Abstract
ABSTRACT - High-grade mucoepidermoid carcinomas (MECs) have difficulty in cure and 5-year survival rateis quiet low. Therefore, we need new therapeutic agents and molecular targets. Betulinic acid (BA) is one of the mate-rials which is easily found in the world and shows tumor-suppress effects in various tumor types. In addition, manykinds of normal tissues have a resistance to BA treatment. In this study, we investigated the anti-proliferative activityof BA and its molecular targets in MC-3 human MEC cells using western blot analysis and DAPI staining. BA inhib-ited cell viability and induced apoptosis in MC-3 cells. It affected Specificity protein 1 (Sp1) and its downstream mol-ecule, survivin whereas it did not affect myeloid cell leukemia-1 (Mcl-1). Therefore, we suggest that BA can be apotential anti-cancer drug candidate regulating Sp 1 and survivin to exert apoptotic cell death.Key words: Betulinic acid, Apoptosis, Mucoepidermoid carcinoma, Specificity protein 1, survivin Introduction
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