Abstract
Currently, there are no proven medical treatments against SARS-CoV-2, the virus responsible for Covid-19. In addition to the all important public health measures needed to prevent the spread of this disease, a number of strategies related to our exposome are recommended herein, to better prevent and mitigate the effects of a SARS-CoV-2 infection through enhancement of our immune system and reduction of inflammation.
Highlights
Nor will humans adapt rapidly enough to remain healthy in an ever changing and expanding exposome, including the newly made more than 2000 chemicals created every year [86]
To better live with the rapidly changing environment being created, new therapeutic strategies must emerge, for example, using systems therapeutics for physiological renormalization [87,88] to bring our bodies into a state of allostasis [89], where the immune system components are in balance to fight infection, and inflammation can be properly resolved
An important example of renormalizing the immune system is in cancer therapeutics where ‘checkpoint inhibitors’ renormalize T cells to attack the tumor, a technology for which the Nobel Prize in Physiology or Medicine was awarded to James Allison [90]
Summary
Future perspective While humans continue to genetically and epigenetically coadapt with our planet, increasing population, rapid and extensive interactions with fellow humans and other organisms, including zoonotic viruses, means that adaptation in humans will not occur as rapidly as that of other biological entities, such as some viruses, which can internally coevolve their subunits in few passages [85]. To better live with the rapidly changing environment being created, new therapeutic strategies must emerge, for example, using systems therapeutics for physiological renormalization [87,88] to bring our bodies into a state of allostasis [89], where the immune system components are in balance to fight infection, and inflammation can be properly resolved.
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