Abstract
Background: Holder pasteurization is commonly used in milk banks. We previously reported that the pattern of temperature and time may be different according to the pasteurizer used.Aim: The aim of our study was to assess the variances in pasteurization using two different devices: a standard pasteurizer (Past STD) and an optimized pasteurizer (Past OPTI).Methods: Immunoglobulin A (IgA), lactoferrin (LF), and lysozyme (LZ) content were assessed before and after pasteurization of 24 donor human milk samples. The impact of the pasteurization device was evaluated by testing 50- to 200-mL samples.Results: Mean temperature and duration of the plateau were 1.5°C lower and 11 min shorter, respectively, with Past OPTI vs. Past STD. The loss of IgA, LF, and LZ was 17.6, 5.6, and 9.8% lower, respectively, with Past OPTI than with Past STD.Conclusions: Accurate control of temperature enabled better preservation of IgA, LF, and LZ in donor milk. Holder pasteurization should be optimized, and new techniques proposed to treat donor milk should be compared with Holder pasteurization performed with a well-controlled device under realistic conditions.
Highlights
Human milk (HM) is the gold standard for very-low-birth-weight infant nutrition
We reported that an optimized pasteurizer produced better results than a noncontrolled one [8]
The benefits of HM are well-documented [6] and most of them are related to the immune component [2, 3] The aim of the study was to assess LF, immunoglobulin A (IgA), and LZ content of donor HM before and after Holder pasteurization using two water pasteurizers: a standard device (Past Standard pasteurizer (STD)) and an optimized device (Past Optimized pasteurizer (OPTI))
Summary
Human milk (HM) is the gold standard for very-low-birth-weight infant nutrition. Its antimicrobial and immunomodulatory components, such as lactoferrin (LF), immunoglobulin A (IgA), or lysozyme (LZ) compensate for the deficit in neonatal immune system and contribute to the prevention of sepsis in these vulnerable infants [1,2,3,4,5]. The mother’s milk is the first choice, but when unavailable, donor HM from a milk bank is the best alternative [6]. The safety of donor HM is a main concern of HM banks and is achieved by pasteurization. The reference method used worldwide is Holder pasteurization, which consists of heating the milk at a low temperature (62.5◦C) for a long duration (30 min). Holder pasteurization is commonly used in milk banks. We previously reported that the pattern of temperature and time may be different according to the pasteurizer used
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