Better beginnings

Abstract

In this volume of The Journal, McLaughlin et al describe studies designed to determine whether alterations in DNA methylation of opioid related genes (ABCB1, CYP2D6, and OPRM1) provide insights into the mechanisms of Neonatal Abstinence Syndrome (NAS). This is clearly an important clinical problem and better understanding of the biology may lead to enhanced management and outcomes. The results show greater DNA methylation in infants requiring treatment for NAS than a control group exposed to smoking and other social challenges and a non-smoking, affluent control group. The data add additional mechanistic insights into opioids' effect on the developing newborn. This is a contemporary area of investigation. These results may help others identify an infant that is likely to develop NAS and opportunities to optimize treatment. Such findings may also be of greatest importance as more children are followed for long-term neurodevelopmental outcomes where we clearly have a gap in our knowledge. Article page 180 ▶ Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent MothersThe Journal of PediatricsVol. 190PreviewTo investigate whether in utero opioid exposure, which has been linked to adverse neurodevelopmental and social outcomes, is associated with altered DNA methylation of opioid-related genes at birth. Full-Text PDF