Abstract
Gut barrier dysfunction and bacterial endotoxin (Lipopolysaccharide; LPS) translocation to the systemic circulation are prominent clinical challenges in cirrhotic patients. Several investigations mentioned the role of oxidative stress in this complication. In the current study, the effects of BET (0.5 and 1 % w: v, gavage) on biomarkers of oxidative stress, tissue histopathological alterations, and LPS translocation in cirrhotic rats was evaluated. Rats underwent bile duct ligation (BDL) and supplemented with BET for 28 consecutive days. Significant increase in ileum and colon reactive oxygen species, lipid peroxidation, oxidized glutathione levels, and protein carbonylation along with decreased antioxidant capacity and reduced glutathione content were evident in BDL rats. Mitochondrial indices were also significantly different in the intestine of BDL animals. Blunted villus, decreased villus number, and inflammation was also detected in the intestine of BDL animals. The serum LPS level was also significantly higher in the BDL group. BET treatment decreased biomarkers of oxidative stress, enhanced mitochondrial function, and mitigated intestinal histopathological alterations. Moreover, BET significantly suppressed LPS translocation to the systemic circulation. The protective role of BET in the intestine of cirrhotic animals could be attributed to the effect of this compound on oxidative stress and its associated events in enterocytes.
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