Beta2-adrenoceptor stimulation has no effect on skeletal muscle glucose uptake.

Abstract

Blockade of the β-adrenergic receptor induces insulin resistance and chronic β-adrenoceptor stimulation improves insulin sensitivity in animals. We tested whether acute β2-adrenoceptor stimulation increased insulin-induced glucose uptake in human forearm skeletal muscle. During a hyperinsulinemic euglycemic clamp procedure, forearm glucose uptake was calculated by multiplying the arteriovenous glucose gradient and forearm blood flow before and during local infusion of the β2-adrenoceptor salbutamol into the brachial artery. β2-Adrenergic stimulation had no effect on insulin-stimulated glucose uptake in human forearm skeletal muscle.