Abstract
Beta thromboglobulin. a platelet specific protein liberated during the release reaction, has been measured in normal individuals (n=285),and in patients presenting with acute chest pain. The latter group consisted of those with acute myocardial infarction (n=19),those with acute myocardial ischaemia (n=21),and those with chest pain of non cardiac origin (n-7). In the patient groups beta thromboglobulin was measured on admission to hospital, and thereafter daily until the patient was discharged. There was no significant difference between the normal population (mean 22.5 ng/ml),and the patients with with non cardiac chest pain (mean .24 ng/ml). There was a significant difference between the normal population and the patients with acute myocardial infarction (mean 34 ng/ml),and acute myocardial ischaemia (mean 33 ng/ml), p<0.001. There was also a significant difference between these two groups and the patients with non cardiac chest pain, p<0.01.We would conclude that platelet activation occurs in acute myocardial infarction and ischaemia, but it is not clear if this is a primary or a secondary phenomenon.
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