Abstract
RECOVERY from sublethal damage by ionizing radiation is considerably reduced or prevented if the organisms are kept in hypoxic conditions between the irradiation fractions1,2. The dependence of the recovery process on metabolic energy has been assumed to be the basis of this effect. But because these experiments were conducted with organisms which are not capable of anaerobic fermentation, it appeared to be desirable to study split-dose recovery in cells which can live and divide anaerobically as well as aerobically. This is relevant to radiotherapy, because many hypoxic cells in tumours might be capable of anaerobic glycolysis.
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