Abstract
The activity of the enzyme B-glucuronidase in the vaginal secretions is attributed to bacterial action and cellular debris in patients without cancer, and to cancer cells, in addition, in women with cervical carcinoma. The pattern of enzyme activity in gynecologic tissues shows a significant difference between benign and malignant vulva, vagina, and cervix but no difference between benign and malignant endometrium or ovary. The differences observed between activities in various gynecologic tissues are independent of cellularity (nitrogen) and water content. Irradiation leads to a decrease in activity of enzyme in vaginal secretions and in tissues, more consistently in the latter. Lymph nodes invaded by cancer contain an increased activity of enzyme.
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