Abstract
To investigate beta-globin gene polymorphism in the Saudi population, samples from 436 individuals from the eastern and north-western provinces of Saudi Arabia were studied using restriction endonucleases Mst II and Hpa I. Three individuals with haemoglobin genotypes AA, AS and SS were identified to each have a 5.6-kilobase (kb) Hpa I fragment in addition to a 13.0-kb fragment. This paper reports for the first time in Saudis a linkage of both the beta A and beta B genes to a 5.6-kb Hpa I fragment.
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