Beta cyclodextrin-based zinc oxide-silver hybrid nanoparticles: a study on antibacterial activity of its effect on treatment against bacterial skin disease

Abstract

In this report, the hybrid nanoparticles were synthesized in a single step by a new chemical process using beta-cyclodextrin. The nanoparticles were prepared by reduction of silver and zinc oxide precursors with sodium hydroxide in the presence of beta-cyclodextrin(β-CD). Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS) analysis confirmed the successful formation of Ag/ZnO nanoparticles. As per EDS, the weight of silver and zinc oxide was found to be 43.5 wt% and 50.29% respectively. The anti-bacterial effects were tested separately by using silver, zinc oxide and the hybrid nanoparticles. The minimal inhibitory concentration (MIC) assay was performed against Escherichia coli and Staphylococcus aureus, and antifungal activity was tested using Candida albicans. The anti-bacterial mechanism is also discussed. In the clinical trials are carried out against staphylococcal dermatitis using the cream containing hybrid nanoparticles. The clinical studies confirmed the prepared hybrid nanoparticles cream is highly suitable for the treatment against staphylococcus dermatitis.