Abstract
This minireview provides current summaries of beta-blocker use in the management of hypertension and/or chronic kidney disease. Accumulated evidence suggests that atenolol is not sufficiently effective as a primary tool to treat hypertension. The less-than-adequate effect of beta-blockers in lowering the blood pressure and on vascular protection, and the unfavorable effects of these drugs, as compared to other antihypertensive agents, on the metabolic profile have been pointed out. On the other hand, in patients with chronic kidney disease, renin-angiotensin system blockers are the drugs of first choice for achieving the goal of renal protection. Recent studies have reported that vasodilatory beta-blockers have adequate antihypertensive efficacy and less harmful effects on the metabolic profile, and also exert beneficial effects on endothelial function and renal protection. However, there is still not sufficient evidence on the beneficial effects of the new beta-blockers.
Highlights
This minireview provides current summaries of beta-blocker use in the management of hypertension and/or chronic kidney disease
Beta-blockers are recommended as second-line agents after RA system blockers for controlling hypertension in patients with chronic kidney disease (CKD) and systolic heart failure
As compared to other antihypertensive agents, except RA system blockers, it has been confirmed that there are no demerits to using betablockers for renal protection
Summary
This minireview provides current summaries of beta-blocker use in the management of hypertension and/or chronic kidney disease. Webb et al reported a meta-analysis in which they described visit-to-visit blood pressure instability in patients receiving beta-blocker treatment [11], and that this instability was associated with an increased risk of stroke [12].
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