Abstract
Beta-blockers are widely used to treat a number of cardiovascular diseases, including heart failure, myocardial infarction, atrial fibrillation, angina and hypertension. By inhibiting the binding of catacholamines to beta receptors in the heart and vasculature, beta-blockers can reduce cardiac contractility, heart rate, blood pressure and cardiac output. A sound understanding of how beta-blockers work and the basis of their recommendation for various indications is needed to promote their safe and effective use in patients. This article briefly describes the physiology of beta-adrenergic receptors, the mechanism of action of beta-blockers and their place in the therapy of cardiovascular disease,
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