Abstract
Beta-blockers are a subgroup of antiarrhythmic drugs that restore and stabilize heart rhythm, primarily by inhibiting beta-adrenergic receptors. Though grouped by their primary target, the beta-adrenergic receptors, beta-blockers vary in target specificity, side-effects, pharmacological and physico-chemical profiles. As many other drugs, beta blockers are amphiphiles and some regulate a range of membrane proteins at similar concentration, suggesting a common mechanism. It is in this context important that membrane proteins are hydrophobically coupled to their host lipid bilayer, meaning that their function may be regulated by changes in bilayer properties.
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