Abstract
Beta-blockade therapy during sepsis has a sound rationale in view of its cardiac, metabolic, inflammatory and other effects [1]. Whether it is safe and efficacious in both good prognosis and poor prognosis patients is yet to be ascertained. We have developed a 72-h fluid-resuscitated rat model of faecal peritonitis, where prognosis can be accurately predicted as early as 6 h post-insult based on the degree of myocardial depression (low stroke volume, high heart rate)[2]. This model offers a useful means of testing safety and efficacy.
Highlights
Beta-blockade therapy during sepsis has a sound rationale in view of its cardiac, metabolic, inflammatory and other effects [1]
At 6 h, animals were divided into predicted survivors or non-survivors depending on a stroke volume cut-off of 0.20 ml
Stroke volume increased with low dose esmolol in predicted non-survivors, and this offset the reduction in heart rate (Figure 1)
Summary
Beta-blockade therapy during sepsis has a sound rationale in view of its cardiac, metabolic, inflammatory and other effects [1]. Whether it is safe and efficacious in both good prognosis and poor prognosis patients is yet to be ascertained. We have developed a 72-h fluid-resuscitated rat model of faecal peritonitis, where prognosis can be accurately predicted as early as 6 h post-insult based on the degree of myocardial depression (low stroke volume, high heart rate)[2]. This model offers a useful means of testing safety and efficacy
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