Abstract
Background and ObjectiveA number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.MethodsA literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.ResultsArg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179–2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417–0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434–0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768–0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).ConclusionsNone of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.
Highlights
Asthma, which is characterized by variable airway obstruction caused by bronchial hyper-reactivity and airway inflammation, is one of the most common chronic respiratory diseases worldwide
This study provides a more sophisticated understanding of ADRB2 gene polymorphism and the risk of asthma
Inclusion and exclusion criteria Studies that fulfilled the following criteria were incorporated into the meta-analysis: (1) case-control studies that evaluated the association between ADRB2 gene polymorphisms and risk of asthma; (2) the genotype distributions or allele frequency of each study was available or sufficient data could be extracted for calculating the odds ratio (OR) with 95% confidence interval (CI)
Summary
Asthma, which is characterized by variable airway obstruction caused by bronchial hyper-reactivity and airway inflammation, is one of the most common chronic respiratory diseases worldwide. The prevalence of asthma varies worldwide, ranging from 0.2% in China to 21.0% in Australia [1]. Recent studies show that asthma is a genetically related disease, with heritability estimates varying between 48% and 79% [2]. An increasing number of studies are focusing on asthma genetics research. Candidate-gene linkage studies, positional cloning, and genome-wide association studies (GWAS) have already identified a large number of asthma susceptibility genes, and one of these, the beta-2 adrenergic receptor (ADRB2, known as b2-AR) gene, has been extensively studied. A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was performed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
