Abstract
Rationale: Open abdominal surgery is frequently associated with excessive inflammatory response and intestinal barrier compromise, leading to the poor clinical outcome. Previously, administration of beta-1 blocker has been shown to effectively reduce inflammation and preserve intestinal barrier function, and the underlying mechanism may be associated with the activation of the autonomic nervous system via cholecystokinin-receptors.This study investigates the effect of beta-1 blocker on the systemic and local inflammatory response and intestinal barrier function in a setting of open abdominal surgery.
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