Abstract
BackgroundAlthough the measurement site at L4–L5 for visceral adipose tissue (VAT) has been commonly accepted, some researchers suggest that additional upper sites (i.e., L1–L2 and L2–L3) are useful for estimating VAT volume. Therefore, determining the optimum measurement site remains challenging and has become important in determining VAT volume. We investigated the influence of a single-slice measurement site on the prediction of VAT volume and changes in VAT volume in obese Japanese men.MethodsTwenty-four men, aged 30–65 years with a mean BMI of 30 kg/m2, were included in a 12-week weight loss program. We obtained continuous T1-weighted abdominal magnetic resonance images from T9 to S1 with a 1.5-T system to measure the VAT area. These VAT areas were then summed to determine VAT volume before and after the program.ResultsSingle-slice images at 3–11 cm above L4–L5 had significant and high correlations with VAT volume at baseline (r = 0.94–0.97). The single-slice image with the highest correlation coefficient with respect to VAT volume was located at 5 cm above L4–L5 (r = 0.97). The highest correlation coefficient between the individual changes in VAT area and changes in VAT volume was located at 6 cm above L4–L5 (r = 0.90).ConclusionsIndividual measurement sites have different abilities to estimate VAT volume and changes in VAT volume in obese Japanese men. Best zone located at 5–6 cm above L4–L5 may be a better predictor of VAT volume than the L4–L5 image in terms of both baseline and changes with weight loss.
Highlights
Obesity is closely associated with various metabolic disorders [1]
Another prior study [25] suggested that the single-slice visceral adipose tissue (VAT) area with the highest correlation with Δtotal VAT volume was located at the L2–L3 level (5–6 cm above L4–L5) after two interventions
The single-slice image with the highest correlation coefficient with respect to VAT volume was located at 5 cm above L4–L5 (r = 0.97)
Summary
Obesity is closely associated with various metabolic disorders [1]. In particular, visceral adipose tissue (VAT) accumulation, which often accompanies obesity, is associated with hypertension, dyslipidemia, type 2 diabetes, and cardiovascular disease (CVD)[2,3]. High-accuracy imaging techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI), have attracted much attention in the estimation of abdominal adipose tissue. An early study [24] with a small sample size showed different relative changes in several VAT depots (i.e., L2– L3, L3–L4, L4–L5) in response to a 4.4 kg weight reduction induced by a liquid formula diet Another prior study [25] suggested that the single-slice VAT area with the highest correlation with Δtotal VAT volume was located at the L2–L3 level (5–6 cm above L4–L5) after two interventions (hypocaloric diet with or without resistance training). These VAT areas were summed to determine VAT volume before and after the program
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