Abstract
Early and accurate diagnosis of osteomyelitis, an inflammatory process of the bone caused by an infective microorganism, is essential for rapid management of the disease by antimicrobial and/or surgical intervention. Historically, diagnosis has been achieved by histological examination, but, more recently, sophisticated molecular imaging techniques (including computed tomography (CT), magnetic resonance imaging, positron emission tomography, single photon emission CT, scintigraphy) that are increasingly used to support diagnoses made from histological data have been reported. For example, scintigraphy has been used to visualize the inflammatory process in vivo using either radiolabeled leukocytes or radiolabeled antigranulocyte monoclonal antibodies (MAbs). Typically, radiolabeling is achieved using technetium-99m (radioactive half-life = 6.02 hours), and the most commonly used MAbs are the Fab fragment of the immunoglobulin (Ig)G antibody directed against the glycoprotein cross-reactive antigen-90 (sulesomab) and an IgG antibody against normal cross-reactive antigen-95 (BW 250/183, besilesomab (Scintimun ® )). The aim of the present review is to
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
