Abstract
Bergenin Improves Antioxidative System in Tert-butyl Hydroperoxide-Induced Oxidative Stress in Mice
Highlights
Xenobiotics are the major causes of liver toxicity and damage due to capability to generate free radical by-products, especially reactive oxygen species (ROS), from hepatic metabolism.[1,2] The high level of ROS can directly damage cells, tissues, and organs, liver, via impairment of their structures and functions.[3,4] As a toxic compound, tert-butyl hydroperoxide (TBHP) is mostly associated with oxidative stress to damage cellular biomolecules, e.g. lipids, proteins, and nucleic acids, and liver tissue.[5]
Treatment with TBHP significantly elevated the plasma levels of AST, ALT, alkaline phosphatase (ALP), ROS, and MDA compared with the controls (p < 0.05)
ROS, principally peroxyl and alkoxyl radicals, generated from hepatic metabolism of TBHP damage biological molecules, tissues, and organs, especially the liver itself. These free radicals attack polyunsaturated fatty acids of the cell membrane leading to cell membrane fragility and loss of selective membrane permeability,[8] which results in hepatic structural damage and the leakage of AST, ALT, and ALP from hepatocytes to circulation.[21]
Summary
Xenobiotics are the major causes of liver toxicity and damage due to capability to generate free radical by-products, especially reactive oxygen species (ROS), from hepatic metabolism.[1,2] The high level of ROS can directly damage cells, tissues, and organs, liver, via impairment of their structures and functions.[3,4] As a toxic compound, tert-butyl hydroperoxide (TBHP) is mostly associated with oxidative stress to damage cellular biomolecules, e.g. lipids, proteins, and nucleic acids, and liver tissue.[5]. Improves Antioxidative System in Tert-butyl Hydroperoxide-Induced Oxidative Stress in Mice. Oxidative stress might be a strategy for attenuation of ROS-induced liver damage, by which consumption of dietary/natural antioxidants may help to maintain an optimal oxidant-antioxidant balance in the body.[9,10,11]. Dietary supplements have generated considerable interest as sources of exogenous antioxidants like gallic acid, which is abundant in vegetables and fruits, e.g. cabbages, grapes, and pomegranates.[12] Gallic acid (Figure 1A) is a phenolic antioxidant, its natural derivatives likely possess similar properties.[12]. The present study examined the ability of bergenin to improve hepatopathology in TBHP-induced oxidative stress in mouse livers by monitoring oxidative stress markers, antioxidative status, and expression of antioxidant enzymes
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