Abstract
We have explored the effects of bergenin on oxidative stress and apoptosis of H9c2 cells induced by oxygen-glucose deprivation as an experimental model of acute myocardial infarction. The results of our studies show a significant decrease in cell viability in a time-dependent manner by oxygen-glucose deprivation. Bergenin attenuated the effect of oxygenglucose deprivation in a dose-dependent fashion by decreasing reactive oxygen species generation and malondialdehyde level and increasing superoxide dismutase level. Additionally, results from flow cytometry and western blot revealed that bergenin attenuated oxygen-glucose-deprivation-induced cell apoptosis by activating SIRT1/FOXO3a/MnSOD pathway. These observations may offer a potential for bergenin as novel therapeutics for acute myocardial infarction treatment.
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